Confirmed Lineups: Iniesta fit to start as Giroud makes European debut for Chelsea
Lionel Messi returns to the starting XI for Barcelona, who are aiming to beat Chelsea for the first time since 2005.
Eight matches have been played between the two since, with six draws in that time, including the last four at Camp Nou.
Andres Iniesta has recovered from injury in time to start for the blaugrana, and takes the place of Philippe Coutinho, who is ineligible having already represented Liverpool in the Champions League this season.
Elsewhere Ousmane Dembele gets the nod over Paulinho on the opposite flank after a strong showing at Malaga, with the hosts switching back to the usual 4-4-2 formation deployed by Ernesto Valverde since his appointment.
For the Blues, Olivier Giroud starts up front to make his first Champions League appearance for the club since signing from Arsenal, beating Spaniard’s Alvaro Morata and Pedro to a place in the starting XI - the latter denied the chance to start back at his former club.
As expected, Gary Cahill drops to the bench along with Davide Zappacosta, replaced by Antonio Rudiger and Victor Moses respectively.