Confirmed Lineups: De Bruyne and Aguero substitutes for potential title crowning Manchester derby

The line-ups are out as Manchester City bid to become the first ever side to wrap at the Premier League title with six games to spare, and against their local rivals now less.

Pep Guardiola will be looking for a reaction from his players after the 3-0 defeat at Anfield in midweek and has made four changes from Wednesday night.

Raheem Sterling will act as a false nine in place of Gabriel Jesus, with Sergio Aguero only fit enough to make the bench, and Danilo starts at right-back in place of Kyle Walker.

Meanwhile Bernardo Silva will start on the right wing, with Ilkay Gundogan dropping back into midfield at the expense of Kevin De Bruyne, who has been left out of the XI for the first time all season in the league.

Finally, Fabian Delph makes his comeback from injury at left-back in place of Aymeric Laporte having not started a league game since mid-January due to injury and suspension, with Manchester City winning 14 of the 15 league matches in which he has been in the XI.

For the visitors there is one change from the side that beat Swansea last time out, with Ander Herrera returning to bolster the midfield area at the expense of compatriot Juan Mata.

The Spaniard has had a real impact on results this season for Manchester United, who have won 80% of the 20 games he has started in the Premier League compared to just 45.5% of the 11 in which he has not been involved from kick-off, so the 29-year-old may feel a little hard done by.